Amido-bridged nucleic acids with small hydrophobic residues enhance hepatic tropism of antisense oligonucleotides in vivo.

نویسندگان

  • Tsuyoshi Yamamoto
  • Aiko Yahara
  • Reiko Waki
  • Hidenori Yasuhara
  • Fumito Wada
  • Mariko Harada-Shiba
  • Satoshi Obika
چکیده

High scalability of a novel bicyclic nucleoside building block, amido-bridged nucleic acid (AmNA), to diversify pharmacokinetic properties of therapeutic antisense oligonucleotides is described. N2'-functionalization of AmNA with a variety of hydrophobic groups is straightforward. Combinations of these modules display similar antisense knockdown effects and improve cellular uptake, relative to sequence-matched conventional 2',4'-bridged nucleic acid (2',4'-BNA) in vivo.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 13 12  شماره 

صفحات  -

تاریخ انتشار 2015